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KMID : 0928320150150040217
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Korean Journal of Health Promotion and Disease Prevention
2015 Volume.15 No. 4 p.217 ~ p.224
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A Cohort study of Gallstones and Incidence of Diabetes in a Korean population
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서병성:Suh Byung-Seong
저자없음:No authors listed
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Abstract
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Background: Gallstones are associated with insulin resistance but the relation between gallstone disease and the risk of developing diabetes mellitus (DM) is unclear. We examined if gallstones are associated with an increased incidence of DM compared to no gallstones.
Methods: A cohort study was performed in 41,518 Koreans aged 30-59 without DM, who underwent a health checkup during 2005-2006 and then were followed annually or biennially until December 2011. Throughout the study period, gallstones were defined as ultrasound-documented gallstones by standard criteria and DM was defined as fasting serum glucose ≥7.0 mmol l-1, A1c ≥6.5%, or use of DM medications.
Results: During 192999 person-years of follow-up, 2,232 participants developed DM (incidence rate 11.6 per 1,000 person-years). The incidence of DM was higher in subjects with gallstones or cholecystectomy than in those without gallstones for women but not for men. In multivariate-adjusted models, the hazard ratios (95% confidence intervals) for DM comparing gallstones and cholecystectomy vs. no gallstones were 0.95 (0.63-1.42) and 1.13 (0.53-2.38), respectively, in men and 1.64 (1.13-2.40) and 2.04 (1.01-4.11), respectively, in women. These associations did not differ significantly between relevant subgroups.
Conclusions: In an apparently healthy population, gallstones were independently and modestly associated with increased incidence for DM in women but not in men. Women with gallstones should be provided with adequate measures for preventing DM.
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KEYWORD
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Gallstones, Diabetes mellitus, Insulin resistance, Cohort study, Incidence
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